Rosemary Lowe-McConnell, obituary

Brian Edmond McConnell

of 48, of Dr. Brian McConnell, one of Bristol's best known and respected practitioner5, I He will be sadly missed by his very wide circle of friends and acquaintances, not oflb in the medical profession but in the broader social world beyond it. A personal friendship which was to last for over twenty years began during the v^f in a disused Cornish sea-side boarding house where, as fellow office...

Lowe syndrome

Lowe syndrome (the oculocerebrorenal syndrome of Lowe, OCRL) is a multisystem disorder characterised by anomalies affecting the eye, the nervous system and the kidney. It is a uncommon, panethnic, X-linked disease, with estimated prevalence in the general population of approximately 1 in 500,000. Bilateral cataract and severe hypotonia are present at birth. In the subsequent weeks or months, a ...

Obituary

Lowe syndrome

Lowe syndrome (LS) is a lethal X-linked genetic disease caused by functional deficiencies of the phosphatidlyinositol 5-phosphatase, Ocrl1. In the past four years, our lab described the first Ocrl1-specific cellular phenotypes using dermal fibroblasts from LS patients. These phenotypes, validated in an ocrl1-morphant zebrafish model, included membrane remodeling (cell migration/spreading, fluid...

Obituary Notice

Mrs. Meiklejohn, of St. Paul's, Upper Maze M, Ston January 29th. Her life was spent for the weitare ? many parents could testify to the devotion w i ^ defective children, and She was the first to realise the special _n country. For many years she she opened the first home for such children in defective children, and of was the Principal of this home, and of a home 10 wQmen> another home for dif...